Pain reflex arcs and the cerebellum

Organisms (Interaction and interdependence) · Integration of body systems · note 3 of 9

Pain reflex arcs and the cerebellumSpec C3.1.9, C3.1.10

In short

A pain reflex arc is an involuntary response with skeletal muscle as the effector. A free nerve ending of a sensory neuron in the hand detects pain, the impulse passes to a single interneuron in the grey matter of the spinal cord, then to a motor neuron that makes a muscle contract. The cerebellum coordinates skeletal muscle contraction and balance.

A reflex is a rapid, involuntary response to a stimulus. The pain reflex arc is an example of an involuntary response with skeletal muscle as the effector. Because the spinal cord, not the brain, processes the signal, the response is fast and does not need a conscious decision.

  1. A sharp object pricks the hand. A free sensory nerve ending of a sensory neuron acts as the pain receptor and generates nerve impulses.
  2. The sensory neuron carries impulses to the spinal cord, entering through the dorsal root.
  3. In the grey matter of the spinal cord, the sensory neuron synapses with a single interneuron.
  4. The interneuron synapses with a motor neuron, which carries impulses out of the spinal cord through the ventral root.
  5. The motor neuron stimulates a skeletal muscle (for example the biceps) to contract, pulling the hand away.

Other interneurons also pass impulses up the spinal cord to the brain, so the pain is felt consciously, but only after the withdrawal has already begun.

Pain reflex arc through a transverse section of the spinal cord: a free nerve ending in the skin of the hand, sensory neuron entering through the dorsal root with its cell body in the dorsal root ganglion, synapse with an interneuron in the grey matter, synapse with a motor neuron that leaves through the ventral root to a skeletal muscle in the arm; arrows show the direction of the impulse. (opens full size in a new tab)
The pain reflex arc: sensory neuron → interneuron in the grey matter → motor neuron → skeletal muscle. Arrows show the direction of the impulse.

The cerebellum

The cerebellum, at the back of the brain below the cerebral hemispheres, coordinates skeletal muscle contraction and balance. It receives information about body position from muscles, joints, the inner ear and the eyes, and adjusts the timing and strength of muscle contractions so that movements are smooth and accurate and posture is maintained. It is important in learned motor skills such as walking, riding a bicycle or writing.

Common mistake:

The cerebellum does not start voluntary movements; the cerebral hemispheres do. The cerebellum coordinates them and keeps the body balanced.

Written and checked against the IB Biology HL specification · Updated October 2026

Frequently asked questions

What is the difference between the nervous system and the endocrine system?

The nervous system sends electrical impulses along neurons to specific cells, giving fast, short-lived responses. The endocrine system secretes hormones into the blood, which carries them to all parts of the body, but only target cells with receptors respond. Hormonal responses are slower but usually longer lasting.

What happens in a pain reflex arc?

A free nerve ending in the hand detects pain and a sensory neuron carries impulses to the spinal cord. In the grey matter it synapses with a single interneuron, which passes the impulse to a motor neuron. The motor neuron makes a skeletal muscle contract, pulling the hand away before the pain is felt consciously.

How is heart rate controlled during exercise?

During exercise, blood carbon dioxide rises and pH falls. Chemoreceptors in the aortic and carotid bodies detect this and signal the medulla. The medulla sends impulses along a sympathetic nerve to the heart, increasing heart rate and stroke volume. Baroreceptors detect blood pressure and help return it to normal by negative feedback.

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