Changes in blood supply to organs with activity

Organisms (Continuity and change) · Homeostasis · note 7 of 7

Spec D3.3.11
HL only (what this means)HL only: additional Higher Level content, only for HL students. SL students can skip it. What the labels mean
Download all Homeostasis notes (PDF)Download all notes (PDF)11 pages

Changes in blood supply to organs with activitySpec D3.3.11

In short

The blood supply to organs changes with activity because arterioles dilate or constrict to redirect blood where it is needed. During vigorous physical activity cardiac output rises and most extra blood goes to skeletal muscles, while flow to the gut and kidneys falls. Blood flow to the brain stays roughly constant during sleep, wakeful rest and exercise.

The heart's output is shared between organs. Smooth muscle in the walls of arterioles contracts (vasoconstriction) or relaxes (vasodilation), so blood can be redistributed to match each organ's needs.

Pattern of blood supply in three states
OrganSleepWakeful restVigorous physical activity
Skeletal musclesLow: muscles relaxed and inactiveModerate shareGreatly increased: by far the largest share, for oxygen and glucose supply and removal of CO₂ and heat
GutSubstantial supply continues for digestion and absorptionLarge share, especially after a mealReduced by vasoconstriction, so blood is diverted to muscles
KidneysLarge share for filtrationLarge share for filtrationReduced, so less filtration and less urine
BrainRoughly constantRoughly constantRoughly constant in volume, so a smaller percentage of the increased cardiac output
  • During vigorous activity, cardiac output rises (faster heart rate and larger stroke volume) and arterioles in active muscles dilate.
  • During sleep, cardiac output is at its lowest, and skeletal muscles receive little blood.
  • The brain needs a steady supply of oxygen and glucose at all times, so its flow is kept almost constant.
Grouped bar chart of blood flow in cm³ min⁻¹ (illustrative values) to skeletal muscles, gut, kidneys and brain during sleep, wakeful rest and vigorous physical activity: muscle flow is very high during activity, gut and kidney flow fall during activity, and brain flow is the same in all three states. (opens full size in a new tab)
Blood is redistributed between organs by vasodilation and vasoconstriction of arterioles. Values are illustrative.
Exam tip:

Linking question: for what reasons do organisms need to distribute materials and energy? Redistribution of blood matches oxygen and glucose supply to the organs working hardest.

Quick check

  1. Name four homeostatic variables in humans.

    Show answer

    Body temperature, blood pH, blood glucose concentration and blood osmotic concentration.

  2. Which pancreatic cells secrete glucagon?

    Show answer

    α (alpha) cells of the islets of Langerhans.

  3. State the physiological cause of type 1 diabetes.

    Show answer

    Autoimmune destruction of the β cells, so little or no insulin is secreted.

  4. How does brown adipose tissue generate heat?

    Show answer

    Uncoupled respiration: energy is released as heat instead of being used to make ATP.

  5. HL only What does ADH do to collecting duct cells?

    Show answer

    Moves aquaporins from intracellular vesicles into the cell membrane, increasing water reabsorption.

Written and checked against the IB Biology HL specification · Updated October 2026

Frequently asked questions

Why does homeostasis use negative feedback rather than positive feedback?

Negative feedback reverses any change from the set point, so it returns a variable to normal whether it rises above or falls below it. Positive feedback amplifies a change away from the set point, which would make an imbalance worse. That is why positive feedback only controls processes that must finish quickly, such as childbirth.

How do insulin and glucagon control blood glucose?

When blood glucose rises, β cells in the pancreatic islets secrete insulin, which makes liver and muscle cells absorb glucose and store it as glycogen. When blood glucose falls, α cells secrete glucagon, which makes liver cells break glycogen down and release glucose. Both hormones travel to their target cells in the blood.

What is the difference between type 1 and type 2 diabetes?

In type 1 diabetes the immune system destroys the insulin-secreting β cells, so little or no insulin is made and insulin must be injected. In type 2 diabetes insulin is still produced but target cells become resistant to it. Type 2 is linked to obesity and inactivity and is managed mainly by diet and exercise.

All 5 questions on Homeostasis

Finished homeostasis? Test yourself:Exam questionsFlashcards