Arteries, veins and capillaries

Molecules, Transport and Health · The heart, blood vessels and haemoglobin · note 2 of 6

Arteries, veins and capillariesSpec 1.7

In short

Arteries have thick, elastic, muscular walls to withstand high pressure and recoil to smooth the pulse. Veins have thin walls, wide lumens and valves to return blood at low pressure. Capillaries have walls one cell thick and a narrow lumen, giving a short diffusion distance and slow flow for exchange with cells.

Structure and function of blood vessels
FeatureArteryVeinCapillary
Direction of blood flowAway from the heartTowards the heartBetween arteries and veins (through tissues)
Blood pressureHighLowFalls along the capillary
WallThick, with collagen, smooth muscle and elastic fibresThin, with little muscle or elastic tissueOne layer of flattened endothelial cells
LumenNarrowWideVery narrow (about the width of a red blood cell)
ValvesNone (except at the heart)PresentNone
Main functionCarry blood away from the heart at high pressureReturn blood to the heartExchange of substances between blood and cells
Cross-sections of an artery (narrow lumen, endothelium, thick layer of smooth muscle and elastic fibres, outer collagen), a vein (wide lumen, thin wall) and a capillary (wall of one layer of endothelial cells with a red blood cell filling the lumen), plus a vein cut lengthways with its semilunar valve open for flow towards the heart and closed against backflow. (opens full size in a new tab)
Wall thickness and lumen size match the pressure in each vessel; valves in veins stop backflow.

Arteries

Blood leaves the heart in a high-pressure surge. The wall of an artery contains collagen fibres, which give strength and prevent bursting, and elastic fibres, which stretch as the surge passes and then recoil. This elastic recoil evens out the pressure pulse so blood flows smoothly. Smooth muscle in the wall can contract to narrow the lumen. The inner lining (endothelium) is smooth, which reduces friction.

Veins

By the time blood reaches the veins its pressure is low, so the walls can be thin, with little muscle or elastic tissue. The wide lumen offers little resistance to flow. Valves (semilunar valves) stop blood flowing backwards. Blood is helped towards the heart by contractions of the surrounding skeletal muscles squeezing the veins, and by pressure changes in the chest during breathing.

Capillaries

Capillaries form dense networks close to almost every cell. Their wall is a single layer of flattened endothelial cells, so the diffusion distance is very short. Gaps between the cells allow small molecules and fluid to pass. The lumen is so narrow that red blood cells are squeezed through in single file, which brings them close to the wall. Together, the capillaries have a very large total cross-sectional area, so blood flows slowly. This gives time for exchange of oxygen, carbon dioxide, glucose and wastes.

Exam tip:

Explain each feature with 'so': thick elastic wall so it withstands high pressure and recoils; one cell thick so a short diffusion distance. A list of features without the reason will not get the mark.

Written and checked against the Edexcel International A Level Biology (YBI11) specification · Updated October 2026

Frequently asked questions

Why do large animals need a heart and circulation?

Large animals have a small surface area to volume ratio and long diffusion distances, and active ones have high metabolic rates, so diffusion alone is too slow. A heart pumps blood in bulk (mass transport) through vessels, delivering oxygen and nutrients to all cells quickly and removing waste.

How are arteries, veins and capillaries different?

Arteries have thick, elastic, muscular walls to withstand high pressure. Veins have thin walls, wide lumens and valves to return blood at low pressure. Capillaries have walls one cell thick and a very narrow lumen, giving a short diffusion distance for exchange between blood and cells.

What happens in the cardiac cycle?

The cardiac cycle has three stages. In atrial systole the atria contract and fill the ventricles. In ventricular systole the ventricles contract, the atrioventricular valves shut and the semilunar valves open to force blood out. In cardiac diastole the heart relaxes and the atria refill.

All 5 questions on The heart, blood vessels and haemoglobin