Nervous and hormonal coordination

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Nervous and hormonal coordinationSpec 8.13

In short

Coordination in animals uses two systems. The nervous system sends rapid electrical impulses along neurones to specific effectors, giving short-lived responses. The endocrine system releases hormones into the blood, which act more slowly on target cells and last longer. The hypothalamus links the two systems.

Coordination means that different parts of an animal work together in response to stimuli. It is brought about by the nervous system and by hormones released by the endocrine system. The two work together: the hypothalamus is part of the brain but controls the pituitary gland.

Nervous and hormonal control compared
FeatureNervous controlHormonal control
SignalElectrical impulses (action potentials) and neurotransmittersChemicals (hormones)
Transmitted byNeuronesBlood (plasma)
SpeedVery fast (milliseconds)Slower (seconds to hours)
TargetSpecific effectors, usually one muscle or glandTarget cells with the complementary receptors, which may be widely spread
DurationShort-lived, stops when the stimulus stopsLonger-lasting, because the hormone remains in the blood
ExampleWithdrawal of a hand from a hot objectAdrenaline released from the adrenal glands

Many responses use both. In the ‘fight or flight’ response, nervous impulses from the hypothalamus stimulate the adrenal glands to release adrenaline. The nervous system gives a very fast response, and adrenaline then prolongs and widens it by raising heart rate, ventilation and blood glucose. The hypothalamus also detects changes in the blood and controls the pituitary gland, which secretes hormones that control other endocrine glands.

Exam tip:

In compare questions use matching features: ‘nerves are fast, hormones are slower’ and ‘nervous effects are short-lived, hormonal effects longer-lasting’. Give a statement for both sides.

Written and checked against the Edexcel International A Level Biology (YBI11) specification · Updated October 2026

Frequently asked questions

What is the difference between nervous and hormonal coordination?

Nervous coordination uses electrical impulses along neurones to produce fast, short-lived responses in specific effectors. Hormonal coordination uses chemicals released into the blood, which act more slowly and last longer on any target cells with receptors. The hypothalamus links the two systems by controlling the pituitary gland.

What do the different parts of the brain do?

The cerebral hemispheres control conscious thought, memory and voluntary movement. The hypothalamus regulates temperature, water balance and the pituitary gland. The pituitary secretes hormones. The cerebellum coordinates movement and balance, and the medulla oblongata controls involuntary actions such as heart rate and breathing rate.

What is the difference between MRI and fMRI?

MRI uses a magnetic field and radio waves to make detailed images of brain structure. fMRI uses the same scanner to detect changes in blood oxygen level in the brain over time. Active neurones use more oxygen, so fMRI shows which parts of the brain are working during a task.

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