Genetic variants in non-coding DNASpec 3.9B
A genetic variant is a difference in the DNA sequence. Variants in the non-coding DNA in front of a gene can affect the phenotype without changing the protein itself.
- The variant is in the non-coding DNA, where RNA polymerase binds.
- This can change how well RNA polymerase binds.
- More or less mRNA is made, so the quantity of protein produced is altered.
- The change in the amount of protein can change the phenotype.