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Pathogens and transmission — Cambridge IGCSE Combined Science

What pathogens and transmissible diseases are, direct and indirect transmission, the body's defences, and how public health controls spread.

Spec B10.1Diseases and immunity, subtopic 1 of 2

Revision notes

3 short notes, in the order of the specification. Each one in short:

  1. A pathogen is a disease-causing organism, and bacteria, viruses, fungi and protists can all be pathogens. A transmissible disease is one in which the pathogen can be passed from one host to another. Transmission can be direct, through blood and other body fluids, or indirect, through contaminated surfaces, food, water, animals or air.

  2. The body's defences against pathogens include barriers that keep them out and cells that destroy those that get in. The skin is a tough barrier, nose hairs and mucus trap pathogens, and stomach acid kills most swallowed pathogens. White blood cells destroy pathogens inside the body by ingesting them or by making antibodies.

  3. The spread of disease is controlled by breaking transmission routes so fewer people take in pathogens. The main measures are a clean water supply, hygienic food preparation, good personal hygiene, waste disposal and sewage treatment. For example, treating drinking water and sewage stops water-borne diseases such as cholera from spreading.

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7 exam-style questions (17 marks), each with its mark scheme.

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9 cards: flip them, mark what you knew, and practise the rest.

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The whole of diseases and immunity on one page, so you can see where this subtopic fits.

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Quick check questions

  1. What is a pathogen?

    Show answer

    A disease-causing organism.

  2. What is a transmissible disease?

    Show answer

    A disease in which the pathogen can be passed from one host to another.

  3. Name the body defences in the syllabus.

    Show answer

    Skin, hairs in the nose, mucus, stomach acid and white blood cells.

Written and checked against the Cambridge IGCSE Combined Science (0653) specification · Updated October 2026