Question 1
Paper 1A style
Which is the correct way to write the binomial of the grey wolf?
- Canis Lupus
- canis lupus
- Canis lupus
- Lupus canis
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Answer: C – genus first with a capital letter, species name lowercase, in italics [1]
Question 2
Paper 1A style
Which statement about chromosome numbers is correct?
- All mammals have 46 chromosomes in their body cells.
- Diploid cells have an even number of chromosomes.
- Species with more chromosomes are more complex.
- Chimpanzees have fewer chromosomes than humans.
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Answer: B – chromosomes in diploid cells are in homologous pairs [1]
Question 3
Paper 1A style
What is the main source of genome diversity between individuals of the same species?
- Differences in the number of genes
- Single-nucleotide polymorphisms
- Differences in chromosome number
- Differences in the genetic code
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Answer: B – members of a species share most of their genome; SNPs give some diversity [1]
Question 4
Paper 2A style
(a) State the biological species concept. [1] (b) Outline why it can be an arbitrary decision whether two populations are the same species or different species. [3]
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- (a) a group of organisms that can breed and produce fertile offspring [1]
- (b) speciation is the splitting of one species into two or more [1]
- (b) speciation usually happens gradually / not by a single act [1]
- (b) non-interbreeding populations diverge / become more and more different in their traits [1]
- (b) no clear point at which they become separate species / intermediate stages exist [1]
- (b) interbreeding cannot be tested if populations are geographically separated OWTTE [1]
- max 4
Question 5
Paper 2A style
Humans have 46 chromosomes and chimpanzees have 48. Evaluate the evidence for the hypothesis that human chromosome 2 arose from the fusion of two chromosomes found in a shared primate ancestor.
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- banding pattern of human chromosome 2 matches chimpanzee chromosomes 12 and 13 (2A and 2B) end to end [1]
- telomere sequences found near the middle of chromosome 2 / at the fusion point [1]
- remains of a second (inactive) centromere on chromosome 2 [1]
- gene order (largely) matches that on the two chimpanzee chromosomes [1]
- fusion explains reduction from 48 to 46 / 24 to 23 pairs [1]
- the hypothesis is testable / made predictions that could have been falsified [1]
- evidence supports but does not prove the hypothesis / fusion itself was not observed OWTTE [1]
- max 4
Question 6
Paper 1B style
The table shows approximate haploid genome sizes taken from a genome database. (a) Calculate how many times larger the genome of Paris japonica is than the human genome. [1] (b) Using the data, evaluate the hypothesis that genome size increases with the complexity of an organism. [3] (c) Suggest one reason why some plants have much larger genomes than humans. [1]
| Organism | Group | Genome size / million base pairs |
|---|---|---|
| Escherichia coli | bacterium | 4.6 |
| Saccharomyces cerevisiae | fungus (yeast) | 12 |
| Drosophila melanogaster | insect | 180 |
| Arabidopsis thaliana | flowering plant | 135 |
| Homo sapiens | mammal | 3,100 |
| Triticum aestivum | flowering plant | 16,000 |
| Paris japonica | flowering plant | 149,000 |
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- (a) 149,000 ÷ 3,100 = 48 (times) [1] Accept 48.1
- (b) supported: simplest organisms / bacterium and yeast have the smallest genomes [1]
- (b) not supported: plants such as wheat / Paris japonica have larger genomes than humans [1]
- (b) Arabidopsis and Drosophila have genomes of a similar size / same order of magnitude despite being very different organisms OWTTE [1]
- (b) conclusion: no close correlation between genome size and complexity / hypothesis not supported overall [1]
- (b) only one or a few species per group / small sample of species [1]
- (c) more non-coding / repetitive DNA [1] Accept extra copies of whole chromosome sets / polyploidy
- max 5
Question 7
Paper 2A style
Outline current and potential future uses of whole genome sequencing.
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- sequencing is increasingly fast and cheap, so many genomes can be compared [1]
- current: research into evolutionary relationships between species / comparing numbers of base differences [1]
- current: finding SNPs / variation linked to traits or diseases [1]
- future: personalised medicine [1]
- choosing drugs / doses / predicting disease risk from an individual's genome [1]
- max 3
Question 8
Paper 2B style
HL only (what this means)
HL only: additional Higher Level content, only for HL students. SL students can skip it. What the labels meanExplain the difficulties of applying the biological species concept, and how chromosome number can act as a shared trait within a species.
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- the biological species concept defines a species as organisms that can breed and produce fertile offspring [1]
- asexually reproducing organisms do not interbreed, so the concept cannot be applied [1]
- each clone / individual would be reproductively isolated, making every one a species OWTTE [1]
- bacteria reproduce asexually / by binary fission [1]
- bacteria exchange genes by horizontal gene transfer / plasmids [1]
- genes pass between different species, so species boundaries are blurred [1]
- interbreeding cannot be tested for fossils / geographically separated populations [1]
- members of a species have the same chromosome number [1]
- hybrids of parents with different chromosome numbers are unlikely to be fertile [1]
- chromosomes cannot pair in meiosis, so viable gametes are not produced [1]
- e.g. horse (64) × donkey (62) gives an infertile mule (63) [1]
- max 6
Question 9
Paper 2A style
HL only (what this means)
HL only: additional Higher Level content, only for HL students. SL students can skip it. What the labels mean(a) State two features that should be used when designing a dichotomous key. [2] (b) Outline how environmental DNA can be used to investigate the biodiversity of a pond. [2]
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- (a) each step has two contrasting descriptions / paired choices [1]
- (a) uses features that are easy to observe [1]
- (a) uses features that do not vary within a species / not size or colour [1]
- (a) each choice leads to another numbered step or a name [1]
- (b) water sample taken and DNA extracted [1]
- (b) barcode region copied by PCR and sequenced [1]
- (b) sequences compared with a reference database of barcodes to identify species [1]
- max 4